What is the HCPedia?
HCPedia® is a knowledge platform developed and maintained by Alphalyse to identify and understand host cell proteins (HCPs) in biologics. It combines robust, reproducible LC-MS data with expert annotations to provide our clients with the most accurate picture of residual proteins in biologics.
The HCPedia® includes:
- Thousands of HCPs identified by advanced LC-MS (Liquid Chromatography-Mass Spectrometry)
- Functional annotations of HCPs and their impact on drug products
- A curated library of scientific references, case examples, and analytical trends
Whether you are investigating a specific HCP, troubleshooting a purification issue, or evaluating ELISA coverage, Alphalyse can use HCPedia to provide the knowledge for informed, data-driven decisions.
What is the HCPedia?
HCPedia® is a knowledge platform developed and maintained by Alphalyse to identify and understand host cell proteins (HCPs) in biologics.
It combines robust LC-MS data with expert annotations to give clients an accurate picture of residual proteins in biologics.
The HCPedia® includes:
- 1000s of HCPs identified by advanced LC-MS
- Functional annotations and impact of HCPs on drug products
- A curated library of scientific references, case examples, and analytical trends
Whether you are investigating a specific HCP, troubleshooting a purification issue, or evaluating ELISA coverage, we can use HCPedia to provide you with knowledge for informed, data-driven decisions.
How does it work?
HCPedia® is powered by Alphalyse’s extensive LC-MS dataset from 650+ client projects and 53+ expression systems, to give you insights that go beyond isolated results.
1,000,689+
Total HCPs
41,456+
Unique HCPs
47,509,774+
Total ions
8,518,243+
Total peptides
3,024+
Unique samples
53+
Organisms
The purpose of HCPedia
Designed for scientists, QA teams, and CMC professionals, HCPedia® provides you with a deeper understanding of HCPs and their role in drug development, empowering you to make informed decisions.
HCPedia® helps you:
- Optimize purification strategies by identifying persistent or critical HCPs
- Evaluate up- and downstream manufacturing processes
- Understand the biological function and risk profile of individual HCPs
- Strengthen regulatory submissions with detailed HCP profiles
- Benchmark your results against known datasets to detect trends or outliers
Alphalyse uses HCPedia® to:
- Identify recurring HCPs across different drug types and expression systems for faster troubleshooting
- Support R&D in developing new services and improving analytical protocols
- Enhance internal quality control and ensure consistency in reporting
- Provide customized, data-backed guidance to clients
- Develop tailored analytical strategies
The purpose of HCPedia
HCPedia® provides QA teams, and CMC professionals with a deeper understanding of HCPs and their role in drug development.
HCPedia® helps you:
- Identify persistent or critical HCPs
- Evaluate up- and downstream processes
- Understand the risk of individual HCPs
- Strengthen regulatory submissions
- Benchmark your results against known datasets
Alphalyse uses HCPedia® to:
- Identify recurring HCPs for fast troubleshooting
- Develop new services and improve protocols
- Enhance internal quality control
- Provide data-backed guidance to clients
- Develop tailored analytical strategies
Why use LC-MS based HCP analysis?
Why MS is becoming the gold standard of HCP analysis
Orthogonal method in pharmaceutical analysis
Why measure impurities in gene therapies with LC-MS?
Try the HCPedia
Has your protein been identified by Alphalyse before?
Are you curious if your HCP of interest is documented in HCPedia?
Simply fill out the form and we will let you know:
- If your protein is covered in the HCPedia®
- In which expression systems was detected